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Clinical Studies

Explore our database of over 6,500 clinical studies on light therapy, searchable by keyword. 

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The effects of the helium neon laser on wound healing in rabbits and on human skin fibroblasts in vitro

"The mean epithelialization time was 11±0.63 days for the laser-treated wounds and 12±0.12 days for the control wounds. The difference was not significant. No significant difference was found between the contraction rates of the full-thickness wounds (e.g., on the seventh postoperative day, the average wound area was 70.2±6.75% of original wound area in the laser-treated group and 66.±8.75% in the control group). Histopathologically, epidermal thickening and an increase in dermal vascularity were observed in healed wounds of the laser-treated groups. However, in vitro, this low-energy laser promoted cell growth in human fibroblast cell cultures in 2-and 3-day treated groups (p>0.05)."

Histopathological effects of low level laser therapy on secondary healing of teat wounds in dairy cattle

"The posthealing histoarchitectural view of irradiated specimens, particularly in Groups A and B, suggests that low level laser therapy has a beneficial influence on wound healing."

Effect of different wavelengths of low level laser therapy on wound healing in mice

"No significant difference was observed between the four groups by macroscopic examination. The area of skin defect of the treated groups was significantly smaller than that of the control groups (p < 0.05) from the 1st-13th day after irradiation. For both irradiated and non-irradiated skin defects of treatment groups, Group III was smaller than Group II (p < 0.05) and Group IV was smaller than Group II (p < 0.05) Histological examination of the tissue skin defect showed greater proliferation of connective tissue and blood vessels in the dermis in treated groups than in control."

Evaluation of low level laser therapy on open wound healing of the teat in dairy cattle

"The durations of healing were 18.5 ± 0.5 days for group A; 19 ± 0.7 days for group B; 23 ± 0.7 days for group C; and 24.5 ± 0.5 days for group D, respectively."

Effect of low level energy laser irradiation on wound healing. An experimental study in rats.

"Neither the clinical nor the microscopical examination of the wound healing process revealed any differences between group A1, A2, B1 and B2, during the observation period. This study did not confirm that low level energy laser treatment would affect the wound healing process."

The Effect of Low-Power He-Ne and He-Cd Laser Therapy on Wound Healing of Rats

"A comparison of the He-Ne and He-Cd laser therapy in this study revealed from 1.57 and 7.84% difference of wound healing acceleration. The acceleration was dependent on the laser dose used. The He-Ne laser yielded better healing possibly due to higher tissue penetration."

Effect of low intensity laser radiation on healing of open skin wounds in rats.

"The mean +/- SD of time required for complete closure in control group was 14.1 +/- 0.86 days (range 12-15 day) while irradiated test wounds took only 10.3 +/- 0.68 days (range 9-12 days) to heal (P < 0.001). Granulation tissue was significantly (P < 0.001) more in test than in control wounds. Early epithelisation with increased fibroblastic reaction, leukocytic infiltration and neo vascularisation was seen in the laser irradiated wounds. The collagen hydroxyproline concentration of scar tissue was also significantly higher (P < 0.001) in test group on 17th post-operative day. The study establishes the biostimulatory effects of low intensity laser radiation on healing of skin wounds."

Effects Of Low Incident Energy Levels Of Infrared Laser Irradiation On Healing Of Infected Open Skin Wounds In Rats

"The results of this study were as follows:

(1) The rate of wound closure was significantly increased in LLL irradiation group.

(2) The incidence of swelling indicating the spread of inflammation was significantly decreased in the experimental group."

Low energy laser irradiation treatment for second intention wound healing in horses.

"There were no differences (p > 0.55) observed in the rate of wound healing between the low energy laser irradiated wounds and the control wounds. There was a significant difference (p < 0.006) observed in the rate of healing between the anatomical sites. Tarsal wounds healed more rapidly than fetlock wounds."


Effect of helium-neon and infrared laser irradiation on wound healing in rabbits.

"[L]aser irradiation at 632.8 nm and 904 nm alone or in combination increased tensile strength during wound healing and may have released tissue factors into the systemic circulation that increased tensile strength on the opposite side as well."

"No differences were found in the rate of wound healing or collagen area."

Failure of a helium-neon laser to affect components of wound healing in vitro.

"Cellular proliferation was not affected by irradiation three times a day for 3 days. There was no effect on cellular migration or on the rate of collagen lattice contraction. The rate of collagen synthesis, measured as the incorporation of 3H-proline into collagenase-sensitive protein, was no greater than that of controls and GAG secretion did not increase in the irradiated group. We have not found any significant effects of He-Ne irradiation."

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